Given the natural rubber latex content of stoppers in vaccines vials, and its use as a stopper or plunger in various pre-filled syringes, there is a recognised risk of an allergic reaction in latex-allergic individuals undergoing vaccination. There is little evidence that such a risk exists and if so, it would be extremely small. The following vaccines use latex in their packaging:
In individuals with a severe latex allergy (i.e. previous anaphylaxis), then vaccines supplied in vials or syringes containing latex should be avoided. Where possible an alternative latex-free vaccine should be offered. In the case of vaccines where there is no alternative, a risk-benefit analysis should be undertaken and the vaccine administered if appropriate in a specialist centre.