Yellow fever vaccine and egg allergy

Unlike the MMR vaccine, the yellow fever vaccine does contain significant amounts of egg protein (ranging from 2.4 – 4.4 micrograms/ml) and so it is contraindicated in individuals with an egg allergy. For egg-allergic individuals requiring a yellow fever vaccine, a risk-benefit analysis is undertaken in specialist allergy clinics. This may include skin prick and intradermal testing to the vaccine with a 2-step graded challenge or 7-step desensitisation being undertaken where appropriate. Studies of larger cohorts of egg allergic individuals have indicated that reactions to the vaccine appear to be significantly related to positive intradermal tests.

Announcement

BSACI Global Allergy Online Symposium 2023

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